"The rate of evolution: Is anything understood?"
Framing good quantitative questions about aspects of evolution that involve multiple genetic changes is a major challenge. Answering them is not easier. Various issues associated with one of the most fundamental problems --- the rate of evolution -- will be discussed emphasizing the current state of understanding, key sets of questions, and potential for progress. Starting with problems relevant for laboratory experiments, this will range up to simple models for evolution on long time scales from which useful scaling results and understanding might be gleaned.