Human-technology integration is the replacement of human parts and extension of human capabilities with engineered devices and substrates. Its result is hybrid biological-artificial systems. We discuss here four major categories of products furthering human-technology integration: wearable computers, pervasive computing environments, engineered tissues and organs, and prostetics. We introduce examples of currently realized systems from each category. We then formulate two different predictions regarding the observational consequence of the replacement of every biologically-based human part with an engineered substitute.