ICCS2004 Application Submission/Review

Abstract for
"Assessing lethality in the genome-scale metabolic network of Escherichia coli"

As a first step beyond the pathway analysis, we study the biochemical reaction network occurring in the genome-scale metabolic networks of Escherichia coli. To this end, we construct a directed bipartite graph by mapping metabolite and their associated reactions into alternating vertices. Applying various measures of centrality and introducing the concept of synthetic lethality, we identify lethal reactions involved in the whole-cell metabolism.